Senior Director, Clinical Research-Program Executive-Oncology
virbiotechnologyinc
1 month ago
Full-time
On-site
San Francisco, California, United States
$235,500 - $329,500 USD yearly
Leadership
Moneyboard classification: Published range reaches threshold
Reported USD annual base: $235,500–$329,500
Original source: Greenhouse
Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN® dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies.
Vir Biotechnology has exclusive rights to the universal PRO-XTEN® masking platform for oncology and infectious disease. PRO-XTEN® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company.
We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best.
THE OPPORTUNITY
Vir Biotechnology is seeking an experienced Senior Director, Clinical Research Oncology Program Executive (PE) to serve as the development team leader and single point of accountability for one or more oncology development programs. This highly visible leadership role sits at the intersection of clinical development, program strategy, and corporate execution.
The Oncology PE will be responsible for defining and driving the overall development strategy, ensuring alignment across functions, and leading cross-functional teams to achieve key development milestones. The individual will partner closely with executive leadership to shape program direction, evaluate risks and opportunities, prioritize investments, and ensure successful execution of Vir Bio’s oncology portfolio.
You will be successful in this role if you bring deep oncology drug development experience and enjoy translating complex scientific and clinical insights into clear development strategies. You are comfortable working across functions, influencing decisions at all levels of the organization, and helping teams navigate key development milestones and strategic decisions.
This role is located in our San Francisco headquarters with an expectation of at least 3 days per week in office.
WHAT YOU'LL DO
Serve as the cross-functional leader and single point of accountability for one or more oncology development programs
Define and drive overall program vision, clinical development strategy, key milestones, and integrated development plans
Lead cross-functional program teams to align on objectives, priorities, timelines, resource needs, and risk mitigation strategies
Partner with executive leadership and governance committees to support strategic decision-making and portfolio prioritization
Ensure programs are appropriately resourced and provide oversight and input on major budget and investment decisions
Leverage deep oncology and clinical development expertise to guide development strategy, clinical trial planning, data interpretation, and key program decisions
Represent programs at senior leadership meetings, governance reviews, alliance meetings, regulatory interactions, and other external forums
Mentor and develop team members while helping strengthen program leadership capabilities across the organization
Own the integrated development plan and target product profile, including stage gates, evidence requirements, and clear go/no-go recommendations.
Chair the development team, establish decision rights and accountabilities, resolve issues promptly, and escalate material tradeoffs with a recommendation.
Ensure fit-for-purpose translational medicine, clinical pharmacology, biomarker, companion-diagnostic, and patient-selection strategies from first-in-human development through registration.
Guide indication prioritization, sequencing, combination strategy, and lifecycle planning based on scientific rationale, unmet need, speed to interpretable data, competitive intensity, regulatory feasibility, and commercial opportunity.
Define data-readout and evidence-generation plans that support rapid learning, early de-risking, and disciplined investment.
Partner with Regulatory Affairs on global strategy, health-authority engagement, dose optimization, and expedited-development opportunities supported by data.
Coordinate Clinical Operations, Biometrics, Safety, CMC/Technical Operations, Medical Affairs, and Commercial to ensure integrated execution, inspection readiness, and a coherent program narrative.
Maintain integrated financial, timeline, resource, dependency, and risk scenarios; recommend corrective action as assumptions or data change.
Engage investigators, key opinion leaders, collaborators, and potential partners, incorporating external insights into program strategy.
Incorporate patient burden, feasibility, diversity, access, and clinically meaningful outcomes into program and study decisions.
WHO YOU ARE AND WHAT YOU BRING
MD or PhD; board certification in Oncology, Hematology/Oncology, or a related specialty preferred
15+ years of biotechnology or pharmaceutical industry experience with substantial experience in oncology drug development
Demonstrated success leading cross-functional development programs in a matrix environment
Deep understanding of oncology clinical development, including experience across early and late-stage development
Experience serving as a Medical Director, Clinical Research Physician, Program Team Leader, or comparable development leadership role
Strong strategic thinking and ability to integrate scientific, clinical, regulatory, operational, and commercial considerations into development plans
Exceptional executive communication, facilitation, negotiation, and conflict-resolution skills.
Experience presenting to executive leadership teams, governance committees, boards, and external stakeholders
Track record of advancing an oncology program through a major value inflection point, such as first-in-human entry, proof of concept, dose selection, pivotal initiation, regulato
Reported USD annual base: $235,500–$329,500
Original source: Greenhouse
Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN® dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies.
Vir Biotechnology has exclusive rights to the universal PRO-XTEN® masking platform for oncology and infectious disease. PRO-XTEN® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company.
We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best.
THE OPPORTUNITY
Vir Biotechnology is seeking an experienced Senior Director, Clinical Research Oncology Program Executive (PE) to serve as the development team leader and single point of accountability for one or more oncology development programs. This highly visible leadership role sits at the intersection of clinical development, program strategy, and corporate execution.
The Oncology PE will be responsible for defining and driving the overall development strategy, ensuring alignment across functions, and leading cross-functional teams to achieve key development milestones. The individual will partner closely with executive leadership to shape program direction, evaluate risks and opportunities, prioritize investments, and ensure successful execution of Vir Bio’s oncology portfolio.
You will be successful in this role if you bring deep oncology drug development experience and enjoy translating complex scientific and clinical insights into clear development strategies. You are comfortable working across functions, influencing decisions at all levels of the organization, and helping teams navigate key development milestones and strategic decisions.
This role is located in our San Francisco headquarters with an expectation of at least 3 days per week in office.
WHAT YOU'LL DO
Serve as the cross-functional leader and single point of accountability for one or more oncology development programs
Define and drive overall program vision, clinical development strategy, key milestones, and integrated development plans
Lead cross-functional program teams to align on objectives, priorities, timelines, resource needs, and risk mitigation strategies
Partner with executive leadership and governance committees to support strategic decision-making and portfolio prioritization
Ensure programs are appropriately resourced and provide oversight and input on major budget and investment decisions
Leverage deep oncology and clinical development expertise to guide development strategy, clinical trial planning, data interpretation, and key program decisions
Represent programs at senior leadership meetings, governance reviews, alliance meetings, regulatory interactions, and other external forums
Mentor and develop team members while helping strengthen program leadership capabilities across the organization
Own the integrated development plan and target product profile, including stage gates, evidence requirements, and clear go/no-go recommendations.
Chair the development team, establish decision rights and accountabilities, resolve issues promptly, and escalate material tradeoffs with a recommendation.
Ensure fit-for-purpose translational medicine, clinical pharmacology, biomarker, companion-diagnostic, and patient-selection strategies from first-in-human development through registration.
Guide indication prioritization, sequencing, combination strategy, and lifecycle planning based on scientific rationale, unmet need, speed to interpretable data, competitive intensity, regulatory feasibility, and commercial opportunity.
Define data-readout and evidence-generation plans that support rapid learning, early de-risking, and disciplined investment.
Partner with Regulatory Affairs on global strategy, health-authority engagement, dose optimization, and expedited-development opportunities supported by data.
Coordinate Clinical Operations, Biometrics, Safety, CMC/Technical Operations, Medical Affairs, and Commercial to ensure integrated execution, inspection readiness, and a coherent program narrative.
Maintain integrated financial, timeline, resource, dependency, and risk scenarios; recommend corrective action as assumptions or data change.
Engage investigators, key opinion leaders, collaborators, and potential partners, incorporating external insights into program strategy.
Incorporate patient burden, feasibility, diversity, access, and clinically meaningful outcomes into program and study decisions.
WHO YOU ARE AND WHAT YOU BRING
MD or PhD; board certification in Oncology, Hematology/Oncology, or a related specialty preferred
15+ years of biotechnology or pharmaceutical industry experience with substantial experience in oncology drug development
Demonstrated success leading cross-functional development programs in a matrix environment
Deep understanding of oncology clinical development, including experience across early and late-stage development
Experience serving as a Medical Director, Clinical Research Physician, Program Team Leader, or comparable development leadership role
Strong strategic thinking and ability to integrate scientific, clinical, regulatory, operational, and commercial considerations into development plans
Exceptional executive communication, facilitation, negotiation, and conflict-resolution skills.
Experience presenting to executive leadership teams, governance committees, boards, and external stakeholders
Track record of advancing an oncology program through a major value inflection point, such as first-in-human entry, proof of concept, dose selection, pivotal initiation, regulato