Medical Director, Clinical Development

Moneyboard classification: Published range reaches threshold
Reported USD annual base: $275,000–$300,000
Original source: Greenhouse

Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. With our transformation into a fully integrated oncology company well underway, it’s an exciting time to be part of Team Olema. 

Our lead product candidate, palazestrant, is a novel, orally available complete estrogen receptor antagonist (CERAN) and selective estrogen receptor degrader (SERD) currently in two pivotal Phase 3 clinical trials. We expect top-line data from OPERA-01, our ongoing Phase 3 trial of palazestrant as a monotherapy in patients with second- or third-line ER+/HER2- metastatic breast cancer (MBC), in Q1 2027 which, if positive, could lead to our first potential approval and commercial launch in 2028. OPERA-02, our Phase 3 trial of palazestrant in combination with ribociblib in patients with frontline ER+/HER2- MBC, is enrolling patients. Together with its mechanism of action, pharmacokinetic properties, and the potential to demonstrate activity in both ESR1 wild-type and mutant tumors, palazestrant could transform the metastatic breast cancer treatment paradigm and provide access to a $15 billion global market opportunity. 

Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with the potential to generate further value and meaningfully impact the metastatic breast cancer treatment landscape – particularly in combination with palazestrant. We recently presented encouraging Phase 1 monotherapy data from this program across multiple solid tumor types, are advancing patient enrollment in the ongoing combination arms in MBC, and expect to initiate a Phase 1 study of OP-3136 in combination with Bayer’s darolutamide in metastatic castration-resistant prostate cancer by the end of this year. 

Aspiring to transform the metastatic treatment paradigm is an ambitious endeavor that requires a resolute approach to developing better therapies and passionate colleagues dedicated to helping the patients we serve feel better, longer. Team Olema possesses a deep commitment to a shared purpose, the sustained pursuit of excellence, cultivating the courage required to advance our programs, the drive to succeed, and a collective capacity for adaptability through learning, growth, and evolution. We are a small group of nimble self-starters who bring consistency in our quest for the extraordinary every single day. 

If you’re ready to be part of a tenacious, courageous, agile, and growing team, join us in making a profound impact, together – for our patients, for your career, and for what’s beyond.  

About the Role >>> Medical Director, Clinical Development 

As the Medical Director, you will serve as an Oncology Physician for palazestrant and play a pivotal role in advancing Olema’s late and early-stage clinical pipeline in breast cancer. 

You will contribute to registration-enabling studies by shaping study design, evaluating clinical data, and engaging with regulatory authorities, investigators, and key opinion leaders. Partnering closely with experienced physicians and cross-functional teams, you will ensure scientific rigor, data integrity, and patient-centric decision-making while contributing to biomarker development, publication planning, and external scientific communications. 

This is a unique opportunity to contribute at a pivotal moment in the program’s trajectory and support the advancement of therapies for patients with ER-positive, HER2-negative breast cancer. 

This role will be based in Cambridge, MA and may require up to 20% travel. 

Key Responsibilities 

Provide Medical Leadership and Expertise 

Contribute to registration-enabling studies for palazestrant in combination with other therapies, including study design, regulatory engagement, and investigator collaboration 

Partner across functions to define and implement clinical development strategies and plans for multiple programs 

Serve as the medical expert and point of contact for clinical and scientific questions across internal and external stakeholders 

Participate in interactions with investigators, academic collaborators, thought leaders, and regulatory authorities 

Maintain strong clinical and scientific acumen through ongoing engagement with the oncology community and key scientific meetings 

Design and Deliver High-Impact Clinical Studies 

Provide medical oversight and partner with CROs for the palazestrant  program and ensure alignment with Olema’s values, SOPs, and ethical standards 

Contribute to the development and execution of clinical protocols, amendments, investigator brochures, study reports, abstracts, and manuscripts 

Ensure scientific rigor and data integrity in partnership with cross-functional internal teams (i.e. Clinical Operations, Biostatistics, Safety) and CRO teams 

Evaluate safety, pharmacology, and efficacy data from ongoing and completed studies to inform program strategy and decision-making 

Contribute to regulatory submissions and communications 

Collaborate with preclinical and translational scientists to develop and integrate biomarker strategies 

Support data generation, publication planning, and external communication of study results 

Ideal Candidate Profile: Experienced Oncology Physician Leader 

You are an accomplished clinical development physician who thrives on meaningful, challenging work and is motivated by the opportunity to make a lasting impact on patients’ lives. You bring clinical and scientific expertise, a collaborative mindset, and a hands-on approach to execution. You are also eager to grow professionally, broaden your leadership capabilities, and expand your career by taking on increasing responsibility and helping shape the future of Olema’s clinical development programs. 

Knowledge 

MD (US Board Certified) is required 

Board certification in Oncology, Hematology/Oncology, or related specialty; significant academic or industry experience 

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